058 Human Epithelial Resident Memory Regulatory T Cells

Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human Considering that thick dermis contains more than thin epidermis, current understanding of might be biased toward dermal Tregs. Therefore, we sought to determine phenotype and function epidermal epithelial epidermis epithelium were allowed float on a medium without adding any exogenous cytokines stimulations for two days at 37 °C. Then, emigrants from explants flow cytometry used functional assays. In addition, immunofluorescence samples conducted. Foxp3 was selectively expressed CD4 +CD103 – various epithelia, as it is highly demethylated. + efficiently suppressed proliferation other cells. The generation maintenance independent hair density Langerhans conclusion, with suppressive are present mucosal epithelia.